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This product also contains Hyaluronic acid, why this acid is one of my favorite products to use, you can read about here. wikiHow, Inc. is the copyright holder of this image under U.S. and international copyright laws. Graphical representation of the LineweaverBurk equation showing the inhibition of the monophenolase activity of tyrosinase in the presence of -arbutin 3 mM. This complex could evolve in two ways: by oxidizing the originated o-diphenol to o-quinone and deoxy-tyrosinase, or by delivering the o-diphenol and met-tyrosinase to the medium, which would produce the self-activation of the system. Its great for post-acne redness and scaring, as well as age spots. Bearberry is a traditional herbal agent used in the treatment of urinary tract infections [2]. /okv7@^83Tf3l(_fkI8NNZl[m- 1B)d!Z+b0U8U'2nG! Alpha arbutin is a skin lightening ingredient that is known for its ability to lighten hyperpigmentation, prevent new hyperpigmentation from forming and is used as a skin brightening agent. For full functionality of this site, please enable JavaScript. If you want a product to help with brightening your skin, scars, or hyperpigmentation, you might want to try alpha arbutin. The Ordinary Alpha Arbutin is a 2% concentration, so it shouldnt be irritating for the majority of users. The maximum number of energy evaluations was set to 2,500,000, the number of independent dockings to 200 and the population size to 150. Below are our picks for some of the best products with this ingredient and a few things to know about each. 699.00 594.00 Save: 105.00 15% Off. Both of them use molecular oxygen as cosubstrate [1]. The experimental conditions were [E]0 = 50 nM and R = [L-dopa]0 / [L-tyrosine]0 = 0.042. Many users find that they started to notice results within just a few days of using The Ordinary Alpha Arbutin. While it may not work for everyone, which is always the case with skincare products, overall, The Ordinarys Alpha Arbutin has great reviews for age spots and seems to work well for many people. Scripps Howard News Service. Taking into account that the assay without arbutin does not have a lag period due to the addition of L-dopa (in catalytic amounts ([D] / [M] = 0.042 [1,61]), when -arbutin is added, the activity rate of the enzyme on L-tyrosine varies (Fig 2A Inset). Furthermore, the IC50 values for monophenolase (Fig 2) and diphenolase (Fig 3) activities were not the same, and neither were the apparent inhibition constants (Fig 4 and S3 Fig), as can be seen in Table 1. Spectrophotometric recordings of the effect of different concentrations of -arbutin on the diphenolase activity of tyrosinase, using L-dopa as substrate. Applied topically, it inhibits tyrosinase and thus prevents the formation of melanin. This was calculated by measuring the initial rate of change in absorbance at the max of the corresponding adduct, using different amounts of MBTH. We care because when kojic acid oxidizes . . wikiHow is where trusted research and expert knowledge come together. WHAT'S THE % OF ALPHA ARBUTIN? The docking results agree with these values. It is an ultra-light formula that reduces sun tanning to a great extent after exposure to UV light. Since the hydroquinone is slowly released, the pesky side effects and questionable toxicity of hydroquinone aren't really a big deal. Kinetic characterization of the action of tyrosinase on arbutins. Well, this new-to-me ingredient had me at hello because banishing dark spots and hyperpigmentation is No. Alpha arbutin, atau yang juga ditulis sebagai -arbutin, adalah zat turunan yang dibuat dari hydroquinone. Limonene's nr1 function is definitely being a fragrance component, . Arbutin blocks this activation, which reduces pigmentation from UV rays. S6 Fig. They used the met form of tyrosinase in contrast with this work where the oxy form was selected for docking purposes since the monophenolase activity resides in this form. Total oxygen consumption test in the presence of L-dopa and different concentrations of -arbutin (mM): a) 0, b) 2, c) 5 and d) 20. She also states that alpha arbutin is about 10 times more effective than beta arbutin when it comes to skin-brightening effects, which is why so many are reaching for this powerhouse ingredient when it comes to bettering the skin. S12 Fig. In order to maintain the depigmenting power of the hydroquinone, while decreasing its cytotoxicity, some derivatives of this compound such as -arbutin (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol) and -arbutin (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol), a glycosylated hydroquinones, have been used (Fig 1) [18]. Jose Tudela, This image may not be used by other entities without the express written consent of wikiHow, Inc.
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\u00a9 2023 wikiHow, Inc. All rights reserved. Recording of the formation time of the o-quinone and its fast decay. 2q B~&$BHp#KU broad scope, and wide readership a perfect fit for your research every time. That activity, in turn, limits melanin production in your skin. Contact us to boost your business! Alpha-Arbutin is a glycosylated hydroquinone that was first discovered in bearberry (Arctostapylos uva-ursi) and then in the leaves of lingonberry, Chinese pear, creeping saxifrage, strawberry tree, marjoram, evergreen. (1) Alpha arbutin also has the effect of absorbing ultraviolet rays. ?$k`@b}ZW"M&-J|UTA7p0 In addition to the applications of arbutins in cosmetics, they also have therapeutic applications such as in the treatment of infections of the urinary tract, and for their antioxidant properties, anti-inflammatory properties and antitumor activity [18]. S8 Inset and S9 Inset Figs demonstrate the instability of the o-quinones generated. This image may not be used by other entities without the express written consent of wikiHow, Inc.
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\u00a9 2023 wikiHow, Inc. All rights reserved. The rest of the experimental conditions were [E]0 = 80 nM and [L-dopa]0 = 0.5 mM. Moreover, the degree of inhibition did not reach 100% in either case. We use cookies to make wikiHow great. Use either or because the two dont go well together. This image may not be used by other entities without the express written consent of wikiHow, Inc.
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\n<\/p><\/div>"}, http://www.nardev.com/UploadSection/ProdCat-481-1449729649.pdf, https://www.nps.gov/articles/2wayspurifywater.htm, https://www.dsm.com/personal-care/en_US/events-and-news/press-releases/2015/07-29-alpha-arbutin-safe-for-use.html, https://www.unitconverters.net/volume/drop-to-milliliter.htm. S4 Fig. {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/4\/4e\/Mix-Alpha-Arbutin-Powder-Step-1.jpg\/v4-460px-Mix-Alpha-Arbutin-Powder-Step-1.jpg","bigUrl":"\/images\/thumb\/4\/4e\/Mix-Alpha-Arbutin-Powder-Step-1.jpg\/aid11678782-v4-728px-Mix-Alpha-Arbutin-Powder-Step-1.jpg","smallWidth":460,"smallHeight":345,"bigWidth":728,"bigHeight":546,"licensing":"

\u00a9 2023 wikiHow, Inc. All rights reserved. The stability of the MBTH-quinone adducts and the rapidity of the kinetic assays makes this a suitable method for determining the monophenolase and diphenolase activities of tyrosinase [40,41,44,45] (S1A Fig). wikiHow, Inc. is the copyright holder of this image under U.S. and international copyright laws. Some compounds with resorcinol structure, such as 4-hexylresorcinol [5], 4-n-butylresorcinol [6] or oxyresveratrol [7], and others such as ellagic acid [8], are used as inhibitors of the enzyme in cosmetics and pharmaceutical industries [2]. wikiHow, Inc. is the copyright holder of this image under U.S. and international copyright laws. The data for V0 vs. [arbutin]0 were represented and fitted to the MichaelisMenten equation using the Sigma Plot 9.0 program for Windows [50], providing the maximum rate (Vmax) and the Michaelis constant (KM). Alpha Arbutin is a natural antioxidant derived from the Bearberry plant. The rest of the experimental conditions were [E]0 = 80 nM and [L-dopa]0 = 0.5 mM. This image may not be used by other entities without the express written consent of wikiHow, Inc.
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\u00a9 2023 wikiHow, Inc. All rights reserved. Stock solutions of L-dopa, TBC, and were prepared in 0.15 mM phosphoric acid to prevent auto-oxidation. The -glucosidic bond found in Alpha-Arbutin offers higher stability than the form found in the related Beta-Arbutin. Graphical representations of the LineweaverBurk equation for the inhibition of the monophenolase activity by -arbutin (Fig 4) and -arbutin (Fig 4 Inset) are presented, showing the apparent competitive inhibition with values of 2.29 0.21 mM and 1.42 0.08 mM, respectively. Through the targeting of tyrosinase, alpha arbutin is a skin brightener. Conditions are described in Materials and Methods. Alpha Arbutin 2% + HA is a water-based serum specifically designed to target uneven skin tone and visibly improve pigmentation. Arbutin can even out skin tone and reduce inflammation. The following are some of the most common questions about this product and how to use it. Arbutin is a safer alternative to hydroquinone, with many of the benefits and not the side effects. Milli-Q system (Millipore Corp, Billerica, MA.) Less tyrosine and less melanin leads to lesser pigmentation, dark spots, and a more even complexion. ]WKji2ML'0T};{K(c.pS6pBR2Cmm VEH_%bzn7YvTP4ewNId Lamarkian Genetic Algorithm was chosen to explore the space of active binding to search for the best conformers. Tip: Alpha arbutin is often mixed with kjic acid, vitamin C, or niacinamide to create a homemade skin whitening cream. Alpha-Arbutin blocks epidermal melanin synthesis by inhibiting enzymatic oxidation of Tyrosine and Dopa. Alpha-Arbutin reduces the degree of skin tanning after UV exposure and helps to minimize the appearance of liver spots. Alpha Arbutin contains 0.5% Squalane. A multi-purpose antioxidant serum designed to target mild to moderately uneven skin tone while reducing the signs of aging. Basically, it works as a tyrosinase inhibitor to eliminate the pigment that causes dark spots, leading to brightening effects. Action of tyrosinase on arbutins in the presence of hydrogen peroxide. Alpha arbutin is an ingredient made from bearberry extract. The high performance liquid chromatography assays were made using an Agilent 1200 Rapid Resolution coupled with a photodiode detector (UHPLC-DAD). This cream can be used on areas all over your body, such as the inner thigh area or under the arms. It can also produce hyperpigmentation disorders such as ephelide, freckles, solar lentigines and melasma [2], which are treated with inhibitors of tyrosinase [24]. Its also helpful for dealing with the loss of elasticity. Jose Antonio Teruel-Puche, Total oxygen consumption test (L-tyrosine). Kojic acid and Alpha Arbutin Glow and Lightening Face Cream Enriched with Shea butter & Vitamin E. BeautyByShima. WHAT'S THE % OF ALPHA ARBUTIN? Tyrosinase (EC 1.14.18.1) is a copper enzyme widely distributed in nature. On the other hand, it has been described that -arbutin inhibits the activity of tyrosinase but not its biosynthesis in human melanocyte cultures [24]. Alpha-arbutin and deoxyarbutin are synthetic forms of arbutin, while beta-arbutin is the plant-derived form of arbutin. If youre worried about making a mess, use a funnel to pour the mixture. Alpha arbutin 2% + Hyaluronic acid 1% reduces dark spots and evens out the skin tone. The distance between the oxygen of the peroxide group and the carbon with the hydroxyl group in ortho position facilitates hydroxylation. 0000008070 00000 n [8] The German Institute of Food Research in Potsdam found that intestinal bacteria can transform arbutin into hydroquinone, which creates an environment favorable for intestinal cancer.[9]. Low concentrations of tyrosinase do not show catalytic activity on and -arbutin, so, these compounds are described as inhibitors. The dissociation constants, Kd, calculated for the docking conformations shown in Fig 8 and S11 Fig are 4.4 mM and 2.4 mM for and -arbutin, respectively. For melasma, particularly from being in the sun, alpha arbutin may help. July 25, 2005. Apply sunscreen when you wear it during the day. The experimental conditions were [E]0 = 300 nM, [MBTH]0 = 0.2 mM, [-arbutin]0 = 10 M and DMF 2%. Stay up-to-date on the latest wellness trends, natural remedies, and more. Citation: Garcia-Jimenez A, Teruel-Puche JA, Berna J, Rodriguez-Lopez JN, Tudela J, Garcia-Canovas F (2017) Action of tyrosinase on alpha and beta-arbutin: A kinetic study. Recording of the formation time of the o-quinone and its fast decay. 0000007844 00000 n These compounds were solubilised by adding 2% (v/v) DMF to the reaction medium. Otherwise, the two are very similar in their effects and benefits. Niacinamide, Licorice, Kojic Acid Glow cream. Copyright: 2017 Garcia-Jimenez et al. A. Schematic representation of the mechanism proposed to explain the oxidation of and -arbutin by tyrosinase in the presence of MBTH. When the degree of inhibition (i) was calculated, a hyperbole was obtained (Fig 2A). It has a natural whitening quality that makes it ideal for creams and lotions if you want to achieve lighter skin or cover blemishes. Benefits. Docking poses obtained with AutoDock of -arbutin in the active site of the oxy form of mushroom tyrosinase are shown as sticks. Spectrophotometric recordings of the effect of different concentrations of -arbutin on the monophenolase activity of tyrosinase, using L-tyrosine as substrate. Oxidized limonene can cause allergic contact dermatitis and counts as a frequent skin sensitizer. The atom colors are as follows: red = oxygen, blue = nitrogen, brown = copper, green = carbon, and white = hydrogen. 0000006426 00000 n M = monophenol (L-tyrosine), D = o-diphenol (L-dopa), Q = o-dopaquinone, P = o-quinone from or -arbutin, AOH = ortho-hydroxylated arbutin, Cr = dopachrome, Em = metatyrosinase, Ed = deoxytyrosinase and Eox = oxytyrosinase. The measurements of the initial rate in the isosbestic point (corresponding to the adduct originated by the reaction of and -arbutin with MBTH (Fig 6 Inset and S10 Inset Fig)) were fitted by non-linear regression to Eq 1, thus obtaining the and values for these substrates (Table 2). When it comes to the skin, alpha arbutin is best known (and loved) for its complexion-brightening properties. although there are also claims that arbutin reduces cancer risk. It helps skin to retain moisture and provides a healthy plumped look. It has a natural whitening quality that makes it ideal for creams and lotions if you want to achieve lighter skin or cover blemishes. Structurally, ALPHA-ARBUTIN (IUPAC name: 4-hydroxyphenyl--D-glucopyranoside) is an . This ingredient is a beauty product that can help with hyperpigmentation, melasma, scarring and signs of aging. Tyrosinase is an enzyme that regulates this conversion. More about vegan skincare: Foods Good For Skin Alpha Arbutin Benefits Alpha Arbutin is a synthetic form of Arbutin, a natural version of hydroquinone derived from plant sources such as bearberry and mulberry. Tyrosinase hydroxylates monophenols to o-diphenols through the action of Eox on A, originating the EoxA complex, which becomes EmAOH, which, in turn, can be oxidized giving rise to Ed and o-quinone (P) or Em and o-diphenol (AOH). This was lent weight by the oxygen consumption test with TBC (Fig 5 and 5 Inset), L-dopa (S4 and S4 Inset Fig) or L-tyrosine (S5 and S5 Inset Fig). This is hands-down our favorite product with this ingredient. When you have less tyrosine, you will have a more even complexion overall. Action on -arbutin. The ingredient can also help with post-inflammatory pigmentation. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. S3 Fig. The chromatogram was analysed using the program Agilent ChemStation (Agilent Technologies, Madrid). It can also reduce the formation of melanin. The rest of the experimental conditions were [E]0 = 50 nM and [TBC]0 = 1 mM. Determination of the MBTH saturation concentration. Below well let you know everything thats relevant about this skincare ingredient and highlight our favorite product. e !}$SA( FHd=cGaK?6 w To do this, you would buy the powder and then carefully dissolve it in water first. D = o-diphenol (L-dopa), Q = o-dopaquinone, A = arbutin, Cr = dopachrome, Em = metatyrosinase, Ed = deoxytyrosinase and Eox = oxytyrosinase. The data agree with those from docking studies that showed that the enzyme has a higher affinity for -arbutin. Spectrophotometric recordings of the effect of different concentrations of -arbutin on the diphenolase activity of tyrosinase, using L-dopa as substrate. However, if 3-methyl-2-benzothiazolinone hydrazone hydrochloride hydrate is used, the o-quinone is attacked, so that it becomes an adduct, which can be oxidized by another molecule of o-quinone, generating o-diphenol in the medium. Action of tyrosinase on -arbutin at long times. Antioxidants help fight free-radicals. Group of Synthetic Organic Chemistry, Department of Organic Chemistry, Faculty of Chemistry, University of Murcia, Espinardo, Murcia, Spain. It's been proven to be more stable and work faster . Applying it with an AHA will actually help you absorb more. The experimental conditions were [E]0 = 300 nM, [H2O2]0 = 10 mM and [-arbutin]0 = 0.5 mM. It helps reducing hyperpigmentation and other dark spots. In this video, I will compare 2 Alpha Arbutin 2% + HA bottles. A study on the action of arbutin on tyrosinase and the rest of the enzymes involved in the melanogenesis process showed that this compound does not change the molecular size or the content of tyrosinase, DHICA oxidase (TRP1) or dopachrome tautomerase 2 (TRP2), but that inhibition might affect the process at the post-translational level [25]. The active admixture is a dermatological serum comprised of alpha arbutin, octyl stearate and polyolprepolymer-2, introduced onto the human skin in liposome form for ultra-deep penetration. [2], It can be prepared synthetically from the reaction of acetobromoglucose and hydroquinone in the presence of alkali. Always buy your alpha arbutin from a reputable dealer. This image may not be used by other entities without the express written consent of wikiHow, Inc.
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\u00a9 2023 wikiHow, Inc. All rights reserved. 'qMSPZNr^pq7rrE CX})7=JQT.l@xsx,7^=>kl:5h'.Kw $}$N+s'6cbw 7:_2".3))'LNoO_ However, both ligands are hydroxylated at essentially the same velocity, since the catalytic rate constants, kcat, were found to be similar (Table 2). #3 More expensive but safer. Docking of -arbutin to mushroom tyrosinase has previously been reported to occur at the active site, where it interacts with E256 and N260. wikiHow, Inc. is the copyright holder of this image under U.S. and international copyright laws. This image is not<\/b> licensed under the Creative Commons license applied to text content and some other images posted to the wikiHow website. It combines a high concentration of purified alpha arbutin, a well-known skin-brightening ingredient, with hyaluronic acid. This image is not<\/b> licensed under the Creative Commons license applied to text content and some other images posted to the wikiHow website. This is a higher concentration product that contains 4% arbutin along with licorice and mulberry extract. If you have concerns over sun damage, age spots, melasma, scarring or hyperpigmentation, which so many people do, we advise that you consider trying a product with alpha arbutin. The discrepancy with our results is due to the different tyrosinase form used by the authors [6]. The need for a safer option is important. It must be taken into account that although the activity of the enzyme is almost zero at these concentrations at short times, the addition of hydrogen peroxide transforms Em to Eox (S7 Fig), which is able to hydroxylate arbutin, although the o-quinone that is originated is unstable. 0000001418 00000 n Applied topically, it inhibits tyrosinase and thus prevents the formation of melanin. Determination of Arbutin in the Leaves of Bergenia crassifolia (L.) Fritsch. Meski begitu, ada pula alpha arbutin alami yang ditemukan dalam berbagai tanaman dan buah-buahan. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Determination of the MBTH saturation concentration. "Arbutin works to inhibit tyrosinase, an enzyme present in melanocytes, the pigment-producing cells in the skin," says board-certified dermatologist Tiffany Jow Libby, M.D. Description Alpha Arbutin Powder (4- Hydroxyphenyl--D-glucopyranoside) is a pure, water-soluble, biosynthetic active ingredient. The ortho carbon is found 3.7 from an oxygen atom of the peroxide ion, close enough to allow substrate hydroxylation by the monophenolase activity. The higher affinity of -arbutin could be explained by the additional conformational stability of the glucopyranose ring provided by three anchor points to the protein compared with two in -arbutin. Though beta-arbutin is cheaper than alpha-arbutin, it is more likely to inhibit skin cell growth. Arbutin is less toxic than hydroquinone and less irritation. Alpha-Arbutin blocks epidermal melanin synthesis by inhibiting enzymatic oxidation of Tyrosine and Dopa. Inset. InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1, InChI=1/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1, c1cc(ccc1O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O, Except where otherwise noted, data are given for materials in their. This image may not be used by other entities without the express written consent of wikiHow, Inc.
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\u00a9 2023 wikiHow, Inc. All rights reserved. Once its dissolved you can add it to creams or other products. It is a derivative of hydroquinone but is safer and works better as an effective skin lightening agent. Skin Lightening Mechanism of Alpha Arbutin Required fields are marked *. h9h$)V[4s>,P4;'Y)KRtwrVD>:URl_?;kk{(i&nKCu+hoZ?+z:E_mInw`Sa C`,Q ;]lCD3D \$/a"0.p#8}W9)149@c(f0^S}wor$bB\`^26^7.E%1`YY^L_R^y{#33fLc9M.C nV;Mt;;Nm[=;2Y)- US20060188559A1 - Topical cosmetic compositions comprising alpha arbutin - Google Patents . Formulated with Arbutin and Resorcinol to stimulate cellular turnover and naturally brighten the look of dark spots and 8% Vitamin C to reduce the look of fine lines. The experimental conditions were [E]0 = 100 nM, [-arbutin]0 = 20 mM and DMF 2%. Since your goal is to reduce dark spots and hyperpigmentation, Dobos recommends pairing alpha arbutin with other ingredients that also improve the tone of the skin for best results. Competing interests: The authors have declared that no competing interests exist. You need 5-parts water for every 1-part alpha arbutin. Jose Berna, It is one of the most popular skin lightening ingredients in the world at present and has been used in the treatment of many hyperpigmentation disorders. Users say that it helps fade dark spots, particularly ones that came from sun damage. Antonio Garcia-Jimenez, Promotes lightening/whitening and an even skin tone. Bowman, Lee. 2009 - 2023 MindBodyGreen LLC. This image may not be used by other entities without the express written consent of wikiHow, Inc.
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\u00a9 2023 wikiHow, Inc. All rights reserved. By using our site, you agree to our. Alpha arbutin, on the other hand, is a synthetic derivative of hydroquinonea powerful bleaching agent. Inset. Its non-irritating for the majority of people, and its a relatively affordable product. Just like its sibling, alpha-arbutin is also a skin-brightening, depigmenting agent. If you did use arbutin and feel that you got too much of a lightening effect, if you stopped using it, that would go away. The chemical structures for and -arbutin are available in the PubChem Substance and Compound database [52] through the unique chemical structure identifier CID: 158637 for -arbutin [53], and CID: 346 for -arbutin [54]. In conclusion, combining both alpha arbutin with retinol is a good idea because it will give you a more consistent result. The known derivatives from hydroquinone, and -arbutin, are used as depigmenting agents. This ad is displayed using third party content and we do not control its accessibility features. This product contains an alpha hydroxy acid (AHA) that may increase your skin's sensitivity to the sun and heighten the possibility of sunburn. The information on our site is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. The met and oxy forms of tyrosinase were built by a slight modification of the binuclear copper-binding site as previously described [56]. wikiHow, Inc. is the copyright holder of this image under U.S. and international copyright laws. e0177330. Melanin is the pigmentation thats responsible for dark spots and hyperpigmentation. The Ordinary Alpha Arbutin 2% + HA Boosted with hyaluronic acid to improve its absorption, this light serum delivers a dose of hydration alongside its skin-brightening benefits. Schematic representation of the action mechanism of tyrosinase on monophenols in the absence and the presence of hydrogen peroxide [46]. The action of tyrosinase on this compound has given rise to much discussion and it has been described as inhibitor, substrate or neither one nor the other [16].

alpha arbutin oxidize 2023